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Article

Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells.

Nucleic acids research - 15 Apr 2001

Wang H, Zeng Z C, Perrault A R, Cheng X, Qin W, Iliakis G

Abstract excerpt

Cells of vertebrates remove DNA double-strand breaks (DSBs) from their genome predominantly utilizing a fast, DNA-PKcs-dependent form of non-homologous end joining (D-NHEJ). Mutants with inactive DNA-PKcs remove the majority of DNA DSBs utilizing a slow, DNA-PKcs-independent pathway that does not utilize genes of the RAD52 epistasis group, is error-prone and can therefore be classified as a form of NHEJ (termed...

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Identifiers

PMID: 11292837
DOI: 10.1093/nar/29.8.1653
PMCID: PMC31316

Genes

RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells.PMID 11292837Read ↗

Impact of DNA ligase IV on the fidelity of end joining in human cells.Semantic proximity Read ↗

DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes.Semantic proximity Read ↗

Deficiency of ligase IV leads to reduced NHEJ, accumulation of DNA damage, and can sensitize cells to cancer therapeuticsSemantic proximity Read ↗

Identification of Genes Involved in Repair of DNA Double-Strand Breaks in Mammalian CellsSemantic proximity Read ↗

Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells.Semantic proximity Read ↗

Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient.Semantic proximity Read ↗

DNA-PKcs suppresses illegitimate chromosome rearrangementsSemantic proximity Read ↗

The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants.Semantic proximity Read ↗

DNA-PKcs Suppresses Illegitimate Chromosome RearrangementsSemantic proximity Read ↗

Genetic interactions between BLM and DNA ligase IV in human cells.Semantic proximity Read ↗

Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4Semantic proximity Read ↗

NHEJ deficiency and disease.Semantic proximity Read ↗

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