Article

CCAR1 promotes DNA repair via an unanticipated role in alternative splicing

2023-09-18

Abstract excerpt

<h4>Summary</h4> DNA repair is directly performed by hundreds of core factors and indirectly regulated by thousands of others. We massively expanded a CRISPR inhibition and Cas9-editing screening system to discover factors indirectly modulating homology directed repair (HDR) in the context of ∼18’000 individual gene knockdowns. We focused on CCAR1, a poorly understood gene that we found reduced both HDR and inte...

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Literature Corpus work: 49a79947-4d59-5677-9ac1-0883be3e127f
DOI: 10.1101/2023.09.18.557780

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