Article

H2A.Z chaperones converge on histone H4 acetylation for melanoma cell proliferation

2023-11-26

Abstract excerpt

<h4>ABSTRACT</h4> High levels of H2A.Z promote melanoma cell proliferation and correlate with poor prognosis. However, the role of the two distinct H2A.Z histone chaperone complexes, SRCAP and P400-TIP60, in melanoma remains unclear. Here, we show that individual depletion of SRCAP , P400 , and VPS72 (YL1 ) not only results in loss of H2A.Z deposition into chromatin, but also a striking reduction of H4 acetyl...

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Literature Corpus work: 6eeba725-b9e6-51ed-a3a8-cc42f16f07ce
DOI: 10.1101/2023.11.26.568747

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