PSMD14 drives melanoma cell survival and MAPK inhibitor resistance through histone H2A deubiquitination

Abstract excerpt

<h4>ABSTRACT</h4> Melanoma progression and resistance to targeted therapies remain major clinical challenges, driven in part by the remarkable phenotypic plasticity of melanoma cells. Identifying molecular mechanisms that couple tumor survival to adaptative drug responses is therefore essential. Here, we identify PSMD14, a proteasome-associated deubiquitinase, as an essential regulator of melanoma plasticity, gro...

Topics

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• Autophagy in Disease and Therapy
• Enhancer of Zeste Homolog 2 Protein
• GTP Phosphohydrolases
• Histone Deacetylase Inhibitors Research
• Melanocytes
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

eb947061-3e3d-591d-843e-b9e0a57b0bad

DOI

10.64898/2026.02.27.708453