Article
Ezh2Y641F mutations co-operate with Stat3 to regulate MHC class I antigen processing and alter the tumor immune response in melanoma.
Oncogene - 1 Nov 2022
Zimmerman Sarah M, Nixon Samantha J, Chen Pei Yu, Raj Leela, Smith Sofia R, Paolini Rachel L, Lin Phyo Nay, Souroullas George P
Abstract excerpt
Enhancer of Zeste Homolog 2 (EZH2) is the catalytic component of the Polycomb Repressive Complex 2, a chromatin modifying complex, which mediates methylation of lysine 27 on histone 3 (H3K27me3), a repressive chromatin mark. Genetic alterations in EZH2 in melanoma include amplifications and activating point mutations at tyrosine 641 (Y641) whose underlying oncogenic mechanisms remain largely unknown. Here, we...
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