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Stat3 co-operates with mutant <i>Ezh2</i> <sup>Y641F</sup> to regulate gene expression and limit the anti-tumor immune response in melanoma

2021-06-01

Abstract excerpt

<h4>ABSTRACT</h4> One of the most frequently genetically altered chromatin modifiers in melanoma is the Enhancer of Zeste Homolog 2 ( EZH2 ), the catalytic component of the Polycomb Repressive Complex 2 (PRC2), which methylates lysine 27 on histone 3 (H3K27me3), a chromatin mark associated with transcriptional repression. Genetic alterations in EZH2 in melanoma include amplifications and activating point mutati...

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Literature Corpus work
bdaa4b19-2386-5741-81d2-9c95b2df6d24
DOI
10.1101/2021.06.01.446580
Open publication

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Stat3 co-operates with mutant <i>Ezh2</i> <sup>Y641F</sup> to regulate gene expression and limit the anti-tumor immune response in melanomaDOI 10.1101/2021.06.01.446580
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