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Article

Phosphorylation of H2A.XTyr39 positively regulates DNA damage response and is linked to cancer progression.

The FEBS journal - 1 Dec 2016

Liu Yan, Long Yue-Hong, Wang Shu-Qing, Li Yu-Feng, Zhang Jing-Hua

Abstract excerpt

Double-stranded DNA breaks induce serine phosphorylation of histone H2A.X, producing γ-H2A.X foci that are then recognized by DNA damage response pathway proteins. Formation of γ-H2A.X is therefore critical for the repair of DNA double-stranded breaks and maintenance of genomic stability, and defects in the recognition or repair of double-stranded breaks can result in tumorigenesis. However, key details regarding...

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Source

Identifiers

PMID: 27813335
DOI: 10.1111/febs.13951

Genes

EYA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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