Article

NAT10 promotes chemoresistance of melanoma through regulating N4-acetylcytidine modification of DDX41 and ZNF746 mRNA

2023-12-11

Abstract excerpt

<h4>Background: </h4> Rapidly developed chemoresistance to dacarbazine (DTIC) is one of the major obstacles in management of melanoma in the clinic, however, roles and mechanism of epi-transcriptomic RNA modification in this process have not been investigated. Method We established DTIC-resistant (DR) melanoma cells for bulk RNA-sequencing, expressions of mRNAs was detected using qRT-PCR, and protein levels were...

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Literature Corpus work: b52c485a-27e0-57df-8c68-1c5946d5e2a3
DOI: 10.21203/rs.3.rs-3665909/v1

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