Article

Histone variant H2A.Z mutant suppresses the senescence-associated secretory phenotype

2026-02-17

Abstract excerpt

<h4>ABSTRACT</h4> Cellular senescence features a durable cell-cycle arrest and a pro-inflammatory senescence-associated secretory phenotype (SASP) driven in part by chromatin remodeling. The histone variant H2A.Z plays an essential role in regulating gene expression through modulating nucleosome dynamics and is known to regulate the expression of cell cycle genes during the early stages of cellular senescence. Ho...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 05e3c439-4b13-520b-8222-c314a72495fa
DOI: 10.64898/2026.02.16.706244

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Histone variant H2A.Z mutant suppresses the senescence-associated secretory phenotypeDOI 10.64898/2026.02.16.706244Read

Histone variant H2A.Z mutant suppresses the senescence-associated secretory phenotypeSemantic proximity Read

Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression.Semantic proximity Read

Interrogating the regulatory epigenome of cellular senescenceSemantic proximity Read

The H2A.J histone variant contributes to Interferon-Stimulated Gene expression in senescence by its weak interaction with H1 and the derepression of repeated DNA sequencesSemantic proximity Read

Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stabilitySemantic proximity Read

HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci.Semantic proximity Read

Histone Variant H2A.J Marks Persistent DNA Damage and Triggers the Secretory Phenotype in Radiation-Induced Senescence.Semantic proximity Read

KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory PhenotypeSemantic proximity Read

HMGB2 holds the key to the senescence-associated secretory phenotype.Semantic proximity Read

Human skin aging is associated with increased expression of the histone variant H2A.J in the epidermisSemantic proximity Read

Dynamics of histone H3.3 deposition in proliferating and senescent cells reveals a DAXX-dependent targeting to PML-NBs important for pericentromeric heterochromatin organizationSemantic proximity Read

KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory PhenotypeSemantic proximity Read