Article

Bimodal Regulation of the PRC2 Complex by USP7 Underlies Melanomagenesis

2019-05-18

Abstract excerpt

<h4>ABSTRACT</h4> Although overexpression of EZH2, a catalytic subunit of the polycomb repressive complex 2 (PRC2), is an eminent feature of various cancers, the regulation of its abundance and function remains insufficiently understood. We report here that the PRC2 complex is physically associated with ubiquitin-specific protease USP7 in melanoma cells where USP7 acts to deubiquitinate and stabilize EZH2. Intere...

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Literature Corpus work: 8d9ab1da-04a6-544d-a902-5c1e9b20c7d6
DOI: 10.1101/641977

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