Article

Concomitant acetylation and loading of H2A.Z by NuA4/TIP60 regulate target gene transcription

2025-09-22

Abstract excerpt

<h4>ABSTRACT</h4> The human NuA4/TIP60 complex is a multi-subunit, dual enzymatic epigenetic factor and gene regulator. It bears histone acetyltransferase (HAT) activity towards the canonical histones H2A and H4 and the histone variant H2A.Z, a function that has been linked to gene activation. It also acts as a chromatin remodeling enzyme through ATP-dependent exchange of nucleosomal H2A-H2B dimers with H2A.Z-H2B...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7c401a41-1ecd-54f7-ba88-d48c1d6748f2
DOI: 10.1101/2025.09.22.677705

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Concomitant acetylation and loading of H2A.Z by NuA4/TIP60 regulate target gene transcriptionDOI 10.1101/2025.09.22.677705Read

The multitalented TIP60 chromatin remodeling complex: wearing many hats in epigenetic regulation, cell division and diseasesSemantic proximity Read

The H2A.Z histone variant integrates Wnt signaling in intestinal epithelial homeostasisSemantic proximity Read

NuA4-dependent acetylation of nucleosomal histones H4 and H2A directly stimulates incorporation of H2A.Z by the SWR1 complex.Semantic proximity Read

EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in MiceSemantic proximity Read

The biological functions of Naa10 – from amino-terminal acetylation to human diseaseSemantic proximity Read

Chromatin and transcriptomic profiling uncover dysregulation of the Tip60 HAT/HDAC2 epigenomic landscape in the neurodegenerative brainSemantic proximity Read

Structures of H2A.Z-associated human chromatin remodelers SRCAP and TIP60 reveal divergent mechanisms of chromatin engagementSemantic proximity Read

Post-translational modifications of epigenetic modifier TIP60: their role in cellular functions and cancerSemantic proximity Read

Chromatin and transcriptomic profiling uncover dysregulation of the Tip60 HAT/HDAC2 epigenomic landscape in the neurodegenerative brainSemantic proximity Read

Cellular effects of NAT-mediated histone N-terminal acetylationSemantic proximity Read

EP400NL is required for cMyc-mediated PD-L1 gene activation by forming a transcriptional coactivator complexSemantic proximity Read

Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs.Semantic proximity Read