Article

Autosomal Recessive Alzheimer’s disease (arAD): homozygosity mapping of genomic regions containing arAD loci

2020-02-11

Abstract excerpt

<h4>ABSTRACT</h4> Long runs of homozygosity (ROH) are contiguous stretches of homozygous genotypes, which are a footprint of recent inbreeding and recessive inheritance. The presence of recessive loci is suggested for Alzheimer’s disease (AD). However, the search for recessive variants has been poorly assessed to date. To investigate homozygosity in AD, we performed a fine-scale ROH analysis including 21,100 indi...

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Literature Corpus work: 6ee7ac94-98c9-5e58-9b8e-5c560e0657f5
DOI: 10.1101/2020.02.10.941393

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