Article

Novel Alzheimer’s disease genes and epistasis identified using machine learning GWAS platform

2023-10-05

Abstract excerpt

Alzheimer’s disease (AD) is a complex genetic disease, and variants identified through genome-wide association studies (GWAS) explain only part of its heritability. Epistasis has been proposed as a major contributor to this ‘missing heritability’, however, many current methods are limited to only modelling additive effects. We use VariantSpark, a machine learning (ML) approach to GWAS, and BitEpi, a tool for epist...

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Literature Corpus work: 5e38dc06-88a8-5fc8-a161-5c9af141d009
DOI: 10.1101/2023.10.04.23296569

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