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Article

Analysis of high-risk pedigrees identifies 11 candidate variants for Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2022

Teerlink Craig C, Miller Justin B, Vance Elizabeth L, Staley Lyndsay A, Stevens Jeffrey, Tavana Justina P, Cloward Matthew E, Page Madeline L, Dayton Louisa, Cannon-Albright Lisa A, Kauwe John S K

Abstract excerpt

INTRODUCTION: Analysis of sequence data in high-risk pedigrees is a powerful approach to detect rare predisposition variants. METHODS: Rare, shared candidate predisposition variants were identified from exome sequencing 19 Alzheimer's disease (AD)-affected cousin pairs selected from high-risk pedigrees. Variants were further prioritized by risk association in various external datasets. Candidate variants emerging...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34151536
DOI: 10.1002/alz.12397
PMCID: PMC9291865

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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