Article

Genetic characterization of the ALFA study: Uncovering genetic profiles in the Alzheimer’s<i>continuum</i>

2023-04-28

Abstract excerpt

In 2013, the ALFA (ALzheimer and FAmilies) project was established to investigate pathophysiological changes in preclinical Alzheimer’s disease (AD), and to foster research on early detection and preventive interventions. Since then, it has prospectively followed cognitively unimpaired late/middle-aged participants, most of whom are adult children of AD patients. Risk stratification of cognitively unimpaired indiv...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a5f5ca3c-1451-5ed1-8a43-4c5327b47eaa
DOI: 10.1101/2023.04.26.23289138

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic characterization of the ALFA study: Uncovering genetic profiles in the Alzheimer’s<i>continuum</i>DOI 10.1101/2023.04.26.23289138Read

Genetic characterization of the ALFA study: Uncovering genetic profiles in the Alzheimer's continuum.Semantic proximity Read

The National Institute on Aging Late Onset Alzheimer’s Disease Family Based Study: A Critical Component of the International Effort to Understand Alzheimer’s DiseaseSemantic proximity Read

The National Institute on Aging Late-Onset Alzheimer's Disease Family Based Study: A resource for genetic discovery.Semantic proximity Read

The Spectrum of Genetic Risk in Alzheimer DiseaseSemantic proximity Read

<i>APOE</i> stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers’s diseaseSemantic proximity Read

A non- <i>APOE</i> Polygenic score for Alzheimer’s disease and <i>APOE-ε4</i> have independent associations with dementia in the Health and Retirement StudySemantic proximity Read

Genetics of Alzheimer's disease.Semantic proximity Read

The genetic risk of Alzheimer's disease beyond APOE ε4: systematic review of Alzheimer's genetic risk scores.Semantic proximity Read

What contribution can genetics make to predict the risk of Alzheimer's disease?Semantic proximity Read

Step by step: towards a better understanding of the genetic architecture of Alzheimer’s diseaseSemantic proximity Read

Biobank-scale characterization of Alzheimer’s disease and related dementias identifies potential disease-causing variants, risk factors, and genetic modifiers across diverse ancestriesSemantic proximity Read

Apolipoprotein E in Alzheimer's disease trajectories and the next-generation clinical care pathway.Semantic proximity Read