Article
A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population.
American journal of human genetics - 1 Jul 2007
Liu Fan, Arias-Vásquez Alejandro, Sleegers Kristel, Aulchenko Yurii S, Kayser Manfred, Sanchez-Juan Pascual, Feng Bing-Jian, Bertoli-Avella Aida M, van Swieten John, Axenovich Tatiana I, Heutink Peter, van Broeckhoven Christine, Oostra Ben A, van Duijn Cornelia M
Abstract excerpt
Alzheimer disease (AD) is the most common cause of dementia. We conducted a genome screen of 103 patients with late-onset AD who were ascertained as part of the Genetic Research in Isolated Populations (GRIP) program that is conducted in a recently isolated population from the southwestern area of The Netherlands. All patients and their 170 closely related relatives were genotyped using 402 microsatellite...
Topics
- Age of Onset
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Female
- Genetic Linkage
- Genome, Human
- Genomics
- Haplotypes
- Humans