Article
Extended tracts of homozygosity identify novel candidate genes associated with late-onset Alzheimer's disease.
Neurogenetics - 1 Jul 2009
Nalls M A, Guerreiro R J, Simon-Sanchez J, Bras J T, Traynor B J, Gibbs J R, Launer L, Hardy J, Singleton A B
Abstract excerpt
Large tracts of extended homozygosity are more prevalent in outbred populations than previously thought. With the advent of high-density genotyping platforms, regions of extended homozygosity can be accurately located allowing for the identification of rare recessive risk variants contributing to disease. We compared measures of extended homozygosity (greater than 1 Mb in length) in a population of 837 late-onset...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.