Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank.

Scientific reports - 19 May 2022

Gouveia Catarina, Gibbons Elizabeth, Dehghani Nadia, Eapen James, Guerreiro Rita, Bras Jose

Abstract excerpt

In just over a decade, advances in genome-wide association studies (GWAS) have offered an approach to stratify individuals based on genetic risk for disease. Using recent Alzheimer's disease (AD) GWAS results as the base data, we determined each individual's polygenic risk score (PRS) in the UK Biobank dataset. Using individuals within the extreme risk distribution, we performed a GWAS that is agnostic of AD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Biological Specimen Banks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Multifactorial Inheritance

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 35589863
DOI: 10.1038/s41598-022-12391-2
PMCID: PMC9120074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank.PMID 35589863Read ↗

Common variants in Alzheimer’s disease: Novel association of six genetic variants with AD and risk stratification by polygenic risk scoresSemantic proximity Read ↗

Heterogeneous effects of genetic risk for Alzheimer's disease on the phenome.Semantic proximity Read ↗

Polygenic Risk Scores in Alzheimer's Disease Genetics: Methodology, Applications, Inclusion, and Diversity.Semantic proximity Read ↗

Biobank-wide association scan identifies risk factors for late-onset Alzheimer’s disease and endophenotypesSemantic proximity Read ↗

Biobank-wide association scan identifies risk factors for late-onset Alzheimer's disease and endophenotypes.Semantic proximity Read ↗

Genetic risk in Alzheimer's disease.Semantic proximity Read ↗

Common polygenic variation enhances risk prediction for Alzheimer's disease.Semantic proximity Read ↗

Genomic variants, genes, and pathways of Alzheimer's disease: An overview.Semantic proximity Read ↗

Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimer’s disease riskSemantic proximity Read ↗

Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores.Semantic proximity Read ↗

Stratification by a polygenic risk score of common variation aids in Alzheimer's disease rare variant discovery.Semantic proximity Read ↗

Genomic analyses reveal new insights into Alzheimer's diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.