Article
Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals.
JAMA neurology - 1 Nov 2015
Ghani Mahdi, Reitz Christiane, Cheng Rong, Vardarajan Badri Narayan, Jun Gyungah, Sato Christine, Naj Adam, Rajbhandary Ruchita, Wang Li-San, Valladares Otto, Lin Chiao-Feng, Larson Eric B, Graff-Radford Neill R, Evans Denis, De Jager Philip L, Crane Paul K, Buxbaum Joseph D, Murrell Jill R, Raj Towfique, Ertekin-Taner Nilufer, Logue Mark, Baldwin Clinton T, Green Robert C, Barnes Lisa L, Cantwell Laura B, Fallin M Daniele, Go Rodney C P, Griffith Patrick A, Obisesan Thomas O, Manly Jennifer J, Lunetta Kathryn L, Kamboh M Ilyas, Lopez Oscar L, Bennett David A, Hendrie Hugh, Hall Kathleen S, Goate Alison M, Byrd Goldie S, Kukull Walter A, Foroud Tatiana M, Haines Jonathan L, Farrer Lindsay A, Pericak-Vance Margaret A, Lee Joseph H, Schellenberg Gerard D, St George-Hyslop Peter, Mayeux Richard, Rogaeva Ekaterina
Abstract excerpt
IMPORTANCE: Mutations in known causal Alzheimer disease (AD) genes account for only 1% to 3% of patients and almost all are dominantly inherited. Recessive inheritance of complex phenotypes can be linked to long (>1-megabase [Mb]) runs of homozygosity (ROHs) detectable by single-nucleotide polymorphism (SNP) arrays. OBJECTIVE: To evaluate the association between ROHs and AD in an African American population known...
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