Article

Sex-dependent polygenic effects on the clinical progressions of Alzheimer’s disease

2019-04-18

Abstract excerpt

Sex differences in the manifestations of Alzheimer’s disease (AD) are under intense investigations 1,2 . Despite the emerging importance of polygenic predictions for AD 3–8 , the sex-dependent polygenic effects have not been demonstrated. Here, using a sex crossover analysis, we show that sex-dependent autosomal genetic effects on AD can be revealed by characterizing disease progress via the hazard function. We...

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Literature Corpus work: 6ec5195e-3df6-590f-9071-aad9f927075a
DOI: 10.1101/613893

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