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Polygenic risk and hazard scores for Alzheimer's disease prediction

18 Feb 2019

Abstract excerpt

Abstract Objective Genome‐wide association studies (GWAS) have identified over 30 susceptibility loci associated with Alzheimer's disease (AD). UsingAD GWASdata from the International Genomics of Alzheimer's Project (IGAP), Polygenic Risk Score (PRS) was successfully applied to predict life time risk ofADdevelopment. A recently introduced Polygenic Hazard Score (PHS) is able to quantify individuals with...

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PMID: 30911569
DOI: 10.1002/acn3.716

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