Article

Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer’s Disease in European Populations: Development and Validation

2025-07-28

Abstract excerpt

<h4>Objectives</h4> Polygenic hazard score (PHS) models can be used to predict the age-associated risk for complex diseases, including Alzheimer’s disease (AD). In this study, we present an improved PHS model for AD that incorporates a large number of genetic variants and demonstrates enhanced predictive accuracy for age of onset in European populations compared to alternative models. <h4>Methods</h4> We used th...

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Literature Corpus work: 0dff561c-7a92-597a-8493-0d1a8206ed21
DOI: 10.1101/2025.07.28.25332293

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