Article
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.
PLoS medicine - 1 Mar 2017
Desikan Rahul S, Fan Chun Chieh, Wang Yunpeng, Schork Andrew J, Cabral Howard J, Cupples L Adrienne, Thompson Wesley K, Besser Lilah, Kukull Walter A, Holland Dominic, Chen Chi-Hua, Brewer James B, Karow David S, Kauppi Karolina, Witoelar Aree, Karch Celeste M, Bonham Luke W, Yokoyama Jennifer S, Rosen Howard J, Miller Bruce L, Dillon William P, Wilson David M, Hess Christopher P, Pericak-Vance Margaret, Haines Jonathan L, Farrer Lindsay A, Mayeux Richard, Hardy John, Goate Alison M, Hyman Bradley T, Schellenberg Gerard D, McEvoy Linda K, Andreassen Ole A, Dale Anders M
Abstract excerpt
BACKGROUND: Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost importance. Although genetic studies have identified AD-associated SNPs in APOE and other genes, genetic information has not been integrated into an epidemiological framework for risk prediction. METHODS AND FINDINGS: Using genotype data from 17,008 AD cases and 37,154 controls from the International Genomics of...
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