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Article

Sex-dependent autosomal effects on clinical progression of Alzheimer's disease.

Brain : a journal of neurology - 1 Jul 2020

Fan Chun Chieh, Banks Sarah J, Thompson Wesley K, Chen Chi-Hua, McEvoy Linda K, Tan Chin Hong, Kukull Walter, Bennett David A, Farrer Lindsay A, Mayeux Richard, Schellenberg Gerard D, Andreassen Ole A, Desikan Rahul, Dale Anders M

Abstract excerpt

Sex differences in the manifestations of Alzheimer's disease are under intense investigation. Despite the emerging importance of polygenic predictions for Alzheimer's disease, sex-dependent polygenic effects have not been demonstrated. Here, using a sex crossover analysis, we show that sex-dependent autosomal genetic effects on Alzheimer's disease can be revealed by characterizing disease progress via the hazard...

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Source

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Identifiers

PMID: 32591829
DOI: 10.1093/brain/awaa164
PMCID: PMC7364740

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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