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Article

Sex-related differences in genetically determined Alzheimer’s disease

4 Mar 2025

Abstract excerpt

We reviewed the literature on sex differences in genetically determined Alzheimer’s disease (AD), focusing on autosomal dominant AD (ADAD), Down syndrome-associated AD (DSAD), and APOE4 homozygosity, particularly regarding disease penetrance, symptom onset and clinical progression, and trajectories for markers of amyloidosis (A), tau pathology (T) and neurodegeneration (N). Data suggests that sex differences in...

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PMID: 40103931
DOI: 10.3389/fnagi.2025.1522434

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