Article
Using Polygenic Hazard Scores to Predict Age at Onset of Alzheimer's Disease in Nordic Populations.
Journal of Alzheimer's disease : JAD - 1 Jan 2022
Motazedi Ehsan, Cheng Weiqiu, Thomassen Jesper Q, Frei Oleksandr, Rongve Arvid, Athanasiu Lavinia, Bahrami Shahram, Shadrin Alexey, Ulstein Ingun, Stordal Eystein, Brækhus Anne, Saltvedt Ingvild, Sando Sigrid B, O'Connell Kevin S, Hindley Guy, van der Meer Dennis, Bergh Sverre, Nordestgaard Børge G, Tybjærg-Hansen Anne, Bråthen Geir, Pihlstrøm Lasse, Djurovic Srdjan, Frikke-Schmidt Ruth, Fladby Tormod, Aarsland Dag, Selbæk Geir, Seibert Tyler M, Dale Anders M, Fan Chun C, Andreassen Ole A
Abstract excerpt
BACKGROUND: Polygenic hazard scores (PHS) estimate age-dependent genetic risk of late-onset Alzheimer's disease (AD), but there is limited information about the performance of PHS on real-world data where the population of interest differs from the model development population and part of the model genotypes are missing or need to be imputed. OBJECTIVE: The aim of this study was to estimate age-dependent risk of...
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