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The Association between Polygenic Hazard and Markers of Alzheimer's Disease Following Stratification for APOE Genotype.

Current Alzheimer research - 1 Jan 2020

De Marco Matteo, Manca Riccardo, Kirby Janine, Hautbergue Guillaume M, Blackburn Daniel J, Wharton Stephen B, Venneri Annalena, Alzheimer's Disease Neuroimaging Initiative

Abstract excerpt

BACKGROUND: Research indicates that polygenic indices of risk of Alzheimer's disease are linked to clinical profiles. OBJECTIVE: Given the "genetic centrality" of the APOE gene, we tested whether this held true for both APOE-ε4 carriers and non-carriers. METHODS: A polygenic hazard score (PHS) was extracted from 784 non-demented participants recruited in the Alzheimer's Disease Neuroimaging Initiative and...

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PMID: 33023447
DOI: 10.2174/1567205017666201006161800

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