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Polygenic hazard score models for the prediction of Alzheimer's free survival using the lasso for Cox's proportional hazards model.

Genetic epidemiology - 1 Jan 2025

Hahn Georg, Prokopenko Dmitry, Hecker Julian, Lutz Sharon M, Mullin Kristina, Tanzi Rudolph E, DeSantis Stacia, Lange Christoph

Abstract excerpt

The prediction of the susceptibility of an individual to a certain disease is an important and timely research area. An established technique is to estimate the risk of an individual with the help of an integrated risk model, that is, a polygenic risk score with added epidemiological covariates. However, integrated risk models do not capture any time dependence, and may provide a point estimate of the relative...

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PMID: 38982682
DOI: 10.1002/gepi.22581

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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