Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polygenic hazard scores in preclinical Alzheimer disease.

Annals of neurology - 1 Sept 2017

Tan Chin Hong, Hyman Bradley T, Tan Jacinth J X, Hess Christopher P, Dillon William P, Schellenberg Gerard D, Besser Lilah M, Kukull Walter A, Kauppi Karolina, McEvoy Linda K, Andreassen Ole A, Dale Anders M, Fan Chun Chieh, Desikan Rahul S

Abstract excerpt

Identifying asymptomatic older individuals at elevated risk for developing Alzheimer disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive decline, even after controlling for APOE ɛ4 carrier status. Older individuals in the highest PHS percentiles showed the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Risk Assessment
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alzheimer Disease

Share to Apolipoprotein E4

Share to Disease Progression

Share to Longitudinal Studies

Share to Multifactorial Inheritance

Share to Neuropsychological Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 28940650
DOI: 10.1002/ana.25029
PMCID: PMC5758043

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polygenic hazard scores in preclinical Alzheimer disease.PMID 28940650Read ↗

Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer’s Disease in European Populations: Development and ValidationSemantic proximity Read ↗

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.Semantic proximity Read ↗

Personalized genetic assessment of age associated Alzheimer’s disease riskSemantic proximity Read ↗

Polygenic hazard score: an enrichment marker for Alzheimer’s associated amyloid and tau depositionSemantic proximity Read ↗

Early‐onset Alzheimer's disease explained by polygenic risk of late‐onset disease?Semantic proximity Read ↗

A/T/N polygenic risk score for cognitive decline in old ageSemantic proximity Read ↗

Polygenic risk and hazard scores for Alzheimer's disease predictionSemantic proximity Read ↗

The Association between Polygenic Hazard and Markers of Alzheimer's Disease Following Stratification for APOE Genotype.Semantic proximity Read ↗

Using Polygenic Hazard Scores to Predict Age at Onset of Alzheimer's Disease in Nordic Populations.Semantic proximity Read ↗

An Integrative Multimodal Model for Early Diagnosis of Dementia and Differential Diagnosis of Alzheimer’s Disease Using Neuroimaging, Polygenic Risk, and Cognitive AssessmentsSemantic proximity Read ↗

Polygenic risk of Alzheimer disease is associated with early- and late-life processes.Semantic proximity Read ↗

Genetic Predisposition to Hippocampal Atrophy and Risk of Amnestic Mild Cognitive Impairment and Alzheimer’s DementiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.