Article

Genome-wide association studies of polygenic risk score-derived phenotypes may lead to inflated false positive rates

2022-09-13

Abstract excerpt

In a recent study, a polygenic risk score (PRS) for Alzheimer’s disease was used to construct a new phenotype for a subsequent genome-wide association study (GWAS). Here we show that the applied method, in which the same genetic variants are used to construct the PRS-derived phenotype as well as to assess their effect in a GWAS of the same phenotype, leads to inflated false positive rates. We illustrate this bias...

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Literature Corpus work: 6ec3f3a8-421b-51d6-ab8e-91837e8a077f
DOI: 10.1101/2022.09.10.507410

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