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Development of a Japanese polygenic risk score model for amyloid-β PET imaging in Alzheimer's disease.

Alzheimer's research & therapy - 22 May 2025

Kaishima Misato, Ito Junichi, Takahashi Kentaro, Tai Kenji, Kuromitsu Junro, Bun Shogyoku, Ito Daisuke

Abstract excerpt

BACKGROUND: The use of polygenic risk scores (PRS) for predicting disease risk in Japanese populations, particularly for dementia and related phenotypes, remains markedly unexplored. The aim of this study was to bridge this gap by developing a novel PRS model designed to predict amyloid-β (Aβ) deposition utilizing positron emission tomography (PET) imaging data from a Japanese cohort. METHODS: Using the polygenic...

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PMID: 40405310
DOI: 10.1186/s13195-025-01754-2
PMCID: PMC12096521

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