Article

Overestimated Polygenic Prediction due to Overlapping Subjects in Genetic Datasets

2022-01-22

Abstract excerpt

<h4>ABSTRACT</h4> Recently, polygenic risk score (PRS) has gained significant attention in studies involving complex genetic diseases and traits. PRS is often derived from summary statistics, from which the independence between discovery and replication sets cannot be monitored. Prior studies, in which the independence is strictly observed, report a relatively low gain from PRS in predictive models of binary trai...

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Literature Corpus work: 92ae7b36-0114-5811-8cfe-344284dc6508
DOI: 10.1101/2022.01.19.476997

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