Article

EML4-ALK induces cellular senescence in mortal normal human cells and promotes anchorage-independent growth in hTERT-transduced normal human cells

2020-12-16

Abstract excerpt

<h4>Background: </h4> Chromosomal inversions involving anaplastic lymphoma kinase ( ALK ) and echinoderm microtubule associated protein like 4 ( EML4 ) generate a fusion protein EML4-ALK in non-small cell lung cancer (NSCLC). The understanding of EML4-ALK function can be improved by a functional study using normal human cells. <h4>Methods: </h4>: Here we for the first time conduct such study to examine the effects...

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Literature Corpus work: 6e45a33b-c319-5e4e-b549-4a65fcb22aa6
DOI: 10.21203/rs.3.rs-35307/v3

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