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Article

The EGFR family members sustain the neoplastic phenotype of ALK+ lung adenocarcinoma via EGR1

8 Apr 2013

Abstract excerpt

In non-small cell lung cancer (NSCLC), receptor tyrosine kinases (RTKs) stand out among causal dominant oncogenes, and the ablation of RTK signaling has emerged as a novel tailored therapeutic strategy. Nonetheless, long-term RTK inhibition leads invariably to acquired resistance, tumor recurrence and metastatic dissemination. In ALK+ cell lines, inhibition of ALK signaling was associated with coactivation of...

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PMID: 23567620
DOI: 10.1038/oncsis.2013.7

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