Article

m <sup>6</sup> A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small cell lung cancer

2021-07-07

Abstract excerpt

The modification of N 6 -methyladenosine (m 6 A) in RNA and its eraser ALKBH5, an m 6 A demethylase, play important roles across various steps of human carcinogenesis. However, the involvement of ALKBH5 in non-small cell lung cancer (NSCLC) development remains to be completely elucidated. The current study revealed that the expression of ALKBH5 were increased in NSCLC and increased expression of ALKBH5 worsened...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a83753b0-c105-52d1-af8a-291b75525261
DOI: 10.1101/2021.07.06.451216

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

m <sup>6</sup> A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small cell lung cancerDOI 10.1101/2021.07.06.451216Read

m⁶A Demethylase ALKBH5 Promotes Tumor Cell Proliferation by Destabilizing IGF2BPs Target Genes and Worsens the Prognosis of Patients with Non-Small Cell Lung CancerSemantic proximity Read

Suppression of m6A mRNA modification by DNA hypermethylated ALKBH5 aggravates the oncological behavior of KRAS mutation/LKB1 loss lung cancer.Semantic proximity Read

RNA Demethylase ALKBH5 Promotes Progression and Angiogenesis of Lung Cancer via Regulating the Stability of LncRNA PVT1Semantic proximity Read

LKB1 Loss Upregulates ALKBH5 and Contributes to Aggressive Phenotypes of KRAS Mutated Lung CancerSemantic proximity Read

Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric CancerSemantic proximity Read

Epigenetic Regulation of m6A Modifications in Human CancerSemantic proximity Read

METTL5 enhances the mRNA stability of TPRKB through m6A modification to facilitate the aggressive phenotypes of hepatocellular carcinoma cell.Semantic proximity Read

ALKBH5-mediated m 6 A modification of CDC6 mRNA impairs gastric cancer tumorigenesis and has prognostic significanceSemantic proximity Read

The RNA N6 -methyladenosine modulator HNRNPA2B1 is involved in the development of non-small cell lung cancer.Semantic proximity Read

M6A Methylation Regulators METTL3 and ALKBH5 are Risk Factors for EGFR-Mutant NSCLCSemantic proximity Read

Pan-Cancer Analysis Shows That ALKBH5 Is a Potential Prognostic and Immunotherapeutic Biomarker for Multiple Cancer Types Including GliomasSemantic proximity Read

The m6A demethylase FTO promotes esophageal cancer progression via the YTHDF1/AKT3 signaling networkSemantic proximity Read