Article

EML4-ALK-mediated Activation of the JAK2-STAT Pathway is Critical for Non-small Cell Lung Cancer Transformation

2020-12-01

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> The echinoderm microtubule-associated protein-like-4 anaplastic lymphoma kinase (EML4-ALK) fusion gene was identified in a small subset of non-small cell lung cancer (NSCLC) patients, who responded positively to ALK inhibitors. The aim of this study was to characterize the mechanism of NSCLC transformation by EML4-ALK.<bold>Methods:</bold> HEK293 and NIH3T3 cell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 56474d6d-c577-5eef-851f-34d4706f63c3
DOI: 10.21203/rs.3.rs-116172/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

EML4-ALK-mediated Activation of the JAK2-STAT Pathway is Critical for Non-small Cell Lung Cancer TransformationDOI 10.21203/rs.3.rs-116172/v1Read

EML4‑ALK fusion gene in non‑small cell lung cancer (Review)Semantic proximity Read

The biology and treatment of EML4-ALK non-small cell lung cancer.Semantic proximity Read

EML4-ALK induces cellular senescence in mortal normal human cells and promotes anchorage-independent growth in hTERT-transduced normal human cellsSemantic proximity Read

Clinicopathological characteristics of patients with non-small-cell lung cancer who harbor EML4-ALK fusion gene: a meta-analysis.Semantic proximity Read

Evaluation of EML4-ALK Fusion Proteins in Non–Small Cell Lung Cancer Using Small Molecule InhibitorsSemantic proximity Read

[Research progress in non-small cell lung cancer with concomitant EML4-ALK fusion gene and EGFR gene mutation].Semantic proximity Read

Complex ALK Fusions Are Associated With Better Prognosis in Advanced Non-Small Cell Lung CancerSemantic proximity Read

Clinicopathologic features of non-small-cell lung cancer with EML4-ALK fusion gene.Semantic proximity Read

Molecular breakdown: a comprehensive view of anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer.Semantic proximity Read

Detection of ALK rearrangement by immunohistochemistry in lung adenocarcinoma and the identification of a novel EML4-ALK variant.Semantic proximity Read

Non‐solid oncogenes in solid tumors: <i> EML4–ALK</i> fusion genes in lung cancerSemantic proximity Read

Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer.Semantic proximity Read