Article
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer.
Nature - 2 Aug 2007
Soda Manabu, Choi Young Lim, Enomoto Munehiro, Takada Shuji, Yamashita Yoshihiro, Ishikawa Shunpei, Fujiwara Shin-ichiro, Watanabe Hideki, Kurashina Kentaro, Hatanaka Hisashi, Bando Masashi, Ohno Shoji, Ishikawa Yuichi, Aburatani Hiroyuki, Niki Toshiro, Sohara Yasunori, Sugiyama Yukihiko, Mano Hiroyuki
Abstract excerpt
Improvement in the clinical outcome of lung cancer is likely to be achieved by identification of the molecular events that underlie its pathogenesis. Here we show that a small inversion within chromosome 2p results in the formation of a fusion gene comprising portions of the echinoderm microtubule-associated protein-like 4 (EML4) gene and the anaplastic lymphoma kinase (ALK) gene in non-small-cell lung cancer...
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