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Article

Identification of Novel Isoforms of the <i>EML4-ALK</i> Transforming Gene in Non–Small Cell Lung Cancer

1 Jul 2008

Abstract excerpt

The genome of a subset of non-small-cell lung cancers (NSCLC) harbors a small inversion within chromosome 2 that gives rise to a transforming fusion gene, EML4-ALK, which encodes an activated protein tyrosine kinase. Although breakpoints within EML4 have been identified in introns 13 and 20, giving rise to variants 1 and 2, respectively, of EML4-ALK, it has remained unclear whether other isoforms of the fusion...

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PMID: 18593892
DOI: 10.1158/0008-5472.can-07-6158

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