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Article

The EML4-ALK oncogene: targeting an essential growth driver in human cancer

1 Jan 2015

Abstract excerpt

Targeting of essential growth drivers represents an ideal approach to cancer treatment. To identify such molecules in clinical specimens, we developed a highly sensitive functional screening system based on the preparation of retroviral cDNA expression libraries. By screening such a library of lung adenocarcinoma with a focus formation assay, we discovered the EML4-ALK fusion-type oncogene. A small chromosomal...

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Identifiers

PMID: 25971657
DOI: 10.2183/pjab.91.193

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The EML4-ALK oncogene: targeting an essential growth driver in human cancerPMID 25971657Read ↗

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