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Article

The biology and treatment of EML4-ALK non-small cell lung cancer.

European journal of cancer (Oxford, England : 1990) - 1 Jul 2010

Sasaki Takaaki, Rodig Scott J, Chirieac Lucian R, Jänne Pasi A

Abstract excerpt

The fusion between echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) has recently been identified in a subset of non-small cell lung cancers (NSCLCs). EML4-ALK is most often detected in never smokers with lung cancer and has unique pathologic features. EML4-ALK is oncogenic both in vitro and in vivo and ALK kinase inhibitors are quite effective in pre-clinical model...

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Topics

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Share to Anaplastic Lymphoma Kinase
Share to Enzyme Inhibitors
Share to Gene Rearrangement

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

Share to Oncogene Proteins, Fusion

Share to Protein-Tyrosine Kinases

Share to Receptor Protein-Tyrosine Kinases

Share to Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 20418096
DOI: 10.1016/j.ejca.2010.04.002
PMCID: PMC2888755

Genes

ALK
EML4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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