Non‐solid oncogenes in solid tumors: <i> EML4–ALK</i> fusion genes in lung cancer

Abstract excerpt

It is generally accepted that recurrent chromosome translocations play a major role in the molecular pathogenesis of hematological malignancies but not of solid tumors. However, chromosome translocations involving the e26 transformation-specific sequence transcription factor loci have been demonstrated recently in many prostate cancer cases. Furthermore, through a functional screening with retroviral cDNA...

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