Article

Allele frequency differences of causal variants have a major impact on low cross-ancestry portability of PRS

2022-10-25

Abstract excerpt

Genome-wide association studies (GWAS) are overwhelmingly biased toward European ancestries. Nearly all existing studies agree that transferring genetic predictions from European ancestries to other populations results in a substantial loss of accuracy. This is commonly referred to as low portability of polygenic risk scores (PRS) and is one of the most important barriers to the ethical clinical deployment of PRS....

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Literature Corpus work: 6e2608ed-df2c-56c5-a2c7-60fcd1acc33f
DOI: 10.1101/2022.10.21.22281371

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