Article
Leveraging fine-scale population structure reveals conservation in genetic effect sizes between human populations across a range of human phenotypes
2023-08-09
Abstract excerpt
An understanding of genetic differences between populations is essential for avoiding confounding in genome-wide association studies (GWAS) and understanding the evolution of human traits. Polygenic risk scores constructed in one group perform poorly in highly genetically-differentiated populations, for reasons which remain controversial. We developed a statistical ancestry inference pipeline able to decompose anc...
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Identifiers and source
- Literature Corpus work
- 4986aad7-f10d-5b15-aad4-5d6309797934
- DOI
- 10.1101/2023.08.08.552281