Article
Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements.
Nature genetics - 1 Dec 2020
Amariuta Tiffany, Ishigaki Kazuyoshi, Sugishita Hiroki, Ohta Tazro, Koido Masaru, Dey Kushal K, Matsuda Koichi, Murakami Yoshinori, Price Alkes L, Kawakami Eiryo, Terao Chikashi, Raychaudhuri Soumya
Abstract excerpt
Poor trans-ancestry portability of polygenic risk scores is a consequence of Eurocentric genetic studies and limited knowledge of shared causal variants. Leveraging regulatory annotations may improve portability by prioritizing functional over tagging variants. We constructed a resource of 707 cell-type-specific IMPACT regulatory annotations by aggregating 5,345 epigenetic datasets to predict binding patterns of...
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