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Article

Mapping the relative accuracy of cross-ancestry prediction.

Nature communications - 2 Dec 2024

Lupi Alexa S, Vazquez Ana I, de Los Campos Gustavo

Abstract excerpt

The overwhelming majority of participants in genome-wide association studies (GWAS) have European (EUR) ancestry, and polygenic scores (PGS) derived from EURs often perform poorly in non-EURs. Previous studies suggest that between-ancestry differences in allele frequencies and linkage disequilibrium are significant contributors to the poor portability of PGS in cross-ancestry prediction. We hypothesize that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39622843
DOI: 10.1038/s41467-024-54727-8
PMCID: PMC11612447

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