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Article

Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries.

Genome biology - 13 Jan 2022

Liang Yanyu, Pividori Milton, Manichaikul Ani, Palmer Abraham A, Cox Nancy J, Wheeler Heather E, Im Hae Kyung

Abstract excerpt

BACKGROUND: Polygenic risk scores (PRS) are valuable to translate the results of genome-wide association studies (GWAS) into clinical practice. To date, most GWAS have been based on individuals of European-ancestry leading to poor performance in populations of non-European ancestry. RESULTS: We introduce the polygenic transcriptome risk score (PTRS), which is based on predicted transcript levels (rather than...

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Identifiers

PMID: 35027082
DOI: 10.1186/s13059-021-02591-w
PMCID: PMC8759285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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