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Improved multi-ancestry fine-mapping identifies<i>cis</i>-regulatory variants underlying molecular traits and disease risk

2024-04-16

Abstract excerpt

Multi-ancestry statistical fine-mapping of cis -molecular quantitative trait loci ( cis -molQTL) aims to improve the precision of distinguishing causal cis -molQTLs from tagging variants. However, existing approaches fail to reflect shared genetic architectures. To solve this limitation, we present the Sum of Shared Single Effects (SuShiE) model, which leverages LD heterogeneity to improve fine-mapping precision,...

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Literature Corpus work
4e749eb2-e6a8-56d6-831a-9496513d39de
DOI
10.1101/2024.04.15.24305836
Open publication

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Improved multi-ancestry fine-mapping identifies<i>cis</i>-regulatory variants underlying molecular traits and disease riskDOI 10.1101/2024.04.15.24305836
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