Article

Histone deacetylase inhibition expands cellular proteostasis repertoires to enhance neuronal stress resilience

2024-08-22

Abstract excerpt

Neurons are long-lived, terminally differentiated cells with limited regenerative capacity. The maintenance of proteostasis and membrane protein trafficking is essential for neuronal function throughout development and aging. Cellular stressors, including endoplasmic reticulum (ER) protein folding stress and endosomal membrane trafficking stress, accumulate as neurons age and correlate with age-dependent neurodege...

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Literature Corpus work: 6e0d652b-1ae6-571d-b213-be15adf897d6
DOI: 10.1101/2024.08.21.608176

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