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General control nonderepressible 2 (GCN2) as a therapeutic target in age-related diseases

10 Sept 2024

Abstract excerpt

The function of General Control Nonderepressible 2 (GCN2), an evolutionary-conserved component of the integrated stress response (ISR), has been well-documented across organisms from yeast to mammals. Recently GCN2 has also gained attention for its role in health and disease states. In this review, we provide a brief overview of GCN2, including its structure, activation mechanisms and interacting partners, and...

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PMID: 39319345
DOI: 10.3389/fragi.2024.1447370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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