Article

A leukemia-derived ENL/AF9 chemical probe enhances neuronal stress resilience and ameliorates ALS phenotypes

2026-04-13

Abstract excerpt

<h4>SUMMARY</h4> Chemical perturbation of chromatin reader proteins provides a precise strategy to interrogate epigenetic control of neuronal stress adaptation. ENL and AF9 are YEATS-domain acyl-lysine readers best characterized in leukemia, but their roles in neurons remain unclear. Here, we use the selective YEATS inhibitor SR-0813 to define ENL/AF9 function in neuronal stress responses across Drosophila and h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a16b5f86-3aab-53b8-b9c8-0d632f96c0a0
DOI: 10.64898/2026.04.09.717610

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A leukemia-derived ENL/AF9 chemical probe enhances neuronal stress resilience and ameliorates ALS phenotypesDOI 10.64898/2026.04.09.717610Read

Histone deacetylase inhibition expands cellular proteostasis repertoires to enhance neuronal stress resilienceSemantic proximity Read

Discovery of a pyrazolopyridine alkaloid that mitigates neuronal ER stress and age-related declineSemantic proximity Read

SLFN11-mediated tRNA regulation induces cell death by disrupting proteostasis in response to DNA-damaging agentsSemantic proximity Read

Stress response silencing by an E3 ligase mutated in neurodegeneration.Semantic proximity Read

RNA-seq Analysis Reveals Upregulation in ER -Stress-Related Genes Upon LCL-161 Treatment in SH-SY5Y Human Neuroblastoma CellsSemantic proximity Read

The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress.Semantic proximity Read

<i>Baldspot/ELOVL6</i> is a conserved modifier of disease and the ER stress response <i>ELOVL6</i> modifies ER stressSemantic proximity Read

ERO1A inhibition mitigates neuronal ER stress and ameliorates UBQLN2ALS phenotypes in Drosophila melanogaster.Semantic proximity Read

Exifone is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of NeurodegenerationSemantic proximity Read

SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243Semantic proximity Read

Nucleolar stress caused by arginine-rich peptides triggers a ribosomopathy and accelerates ageing in miceSemantic proximity Read

Safety and efficacy of <i>C9ORF72</i> -repeat RNA nuclear export inhibition in amyotrophic lateral sclerosisSemantic proximity Read